FISHER SCIENTIFIC -- ACETONITRILE 00170, A21-500  -- -
<pre>=====================  Product Identification  =====================

Product ID:ACETONITRILE 00170, A21-500
MSDS Date:12/12/1998
FSC:NIIN:Submitter:N EN
Status Code:A
=== Responsible Party ===
Company Name:FISHER SCIENTIFIC
Address:1 REAGENT LANE
City:FAIRLAWN
State:NJ
ZIP:07410
Country:US
Info Phone Num:201-796-7100
Emergency Phone Num:(800)424-9300
Chemtrec Ind/Phone:(800)424-9300
CAGE:1B464
=== Contractor Identification ===
Company Name:FISHER SCIENTIFIC CO.  CHEMICAL MFG DIV
Address:1 REAGENT LANE
Box:City:FAIRLAWN
State:NJ
ZIP:07410-2802
Country:US
Phone:201-796-7100
CAGE:1B464

=============  Composition/Information on Ingredients  =============

Ingred Name:ACETONITRILE  LD50: (ORAL, RAT) 2730 MG/KG
CAS:75-05-8
RTECS #:AL7700000
= Wt:99.
OSHA PEL:70 MG/M3;40 PPM
ACGIH TLV:67 MG/M3;40 PPM
ACGIH STEL:101 MG/M3;60 PPM
EPA Rpt Qty:5000 LBS
DOT Rpt Qty:5000 LBS

=====================  Hazards Identification  =====================

LD50 LC50 Mixture:SEE INGREDIENT 1
Routes of Entry: Inhalation:YES  Skin:YES  Ingestion:YES
Reports of Carcinogenicity:NTP:NO    IARC:NO	OSHA:NO
Health Hazards Acute and Chronic:EYE: MAY CAUSE MODERATE EYE IRRIT.
    VAPS MAY CAUSE EYE IRRIT. SKIN: MAY BE HARMFUL IF ABSORBED THRU
    SKIN. MAY BE METABOLIZED TO CYANIDE WHICH IN TURN ACTS BY
    INHIBITING CYTOCHROME OXIDASE IMPAIRING CEL LULAR RESPIRATION.
    INGEST: MAY CAUSE IRRIT OF DIGESTIVE TRACT. MAY CAUSE EFTS SIMILAR
    TO THOSE FOR INHAL EXPOS. INHAL: HARMFUL IF INHALED. INHAL OF HIGH
    CONCS MAY CAUSE CNS EFTS CHARACTERIZED BY HDCH,  DIZZ, UNCON &
    COMA. MAY CAUSE LIVER & KIDNEY DMG. VAPS MAY CAUSE DIZZ OR
    SUFFOCATION. MAY CAUSE NAUS, DIZZ & HDCH. INHAL MAY LEAD TO DIZZ,
    WEAK & DROW, LEADING TO STUPOR, UNCON & EVEN DEATH. INHAL MA Y LEAD
    TO	(EFTS OF OVEREXP)
Effects of Overexposure:HLTH HAZ: HEMATEMESIS, CONVULSIONS, CHOCK, COMA
    & POSSIBLE DEATH. CHRONIC: CHRONIC INHAL & INGEST MAY CAUSE EFTS
    SIMILAR TO THOSE OF ACUTE INHAL & INGEST. MAY BE METABOLIZED TO
    CYANIDE WHICH IN TURN A CTS BY INHIBITING CYTOCHROME OXIDASE
    IMPAIRING CELLULAR RESPIRATION. ANIMAL STUDIES HAVE REPORTED THAT
    FETAL EFTS/ABNORMALITIES MAY OCCUR WHEN MATERNAL TOXICITY IS SEEN.

=======================  First Aid Measures  =======================

First Aid:EYES: FLUSH  W/PLENTY OF WATER FOR AT LEAST 15 MIN, OCCASNLY
    LIFTING UPPER & LOWER LIDS. GET MED AID IMMED. SKIN: GET MED AID
    IMMED. FLUSH SKIN W/PLENTY OF SOAP & WATER FOR AT LEAST 15 MIN
    WHILE REMOV ING CONTAM CLTHG & SHOES. INGEST: IF VICTIM CONSCIOUS &
    ALERT, GIVE 2-4 CUPFULS OF MILK OR WATER. NEVER GIVE ANYTHING BY
    MOUTH TO UNCON PERSON. GET MED AID IMMED.  INHAL: GET MED AID
    IMMED. REMOVE FRO M EXPOS TO FRESH AIR IMMED. IF BRTHG IS DFCLT,
    GIVE OXYG. NOTES TO MD: EXPOS SHOULD BE TREATED AS CYANIDE
    POISONING. EFTS MAY BE DELAYED. ANTIDOTE: ALWAYS HAVE CYANIDE
    ANTIDOTE KIT ON HAND WHEN WORING  W/CYANIDE CMPDS. GET MED ADVICE
    TO USE.

=====================  Fire Fighting Measures  =====================

Flash Point:=6.C, 42.8F
Autoignition Temp:=524.C, 975.2F
Lower Limits:4.4%
Upper Limits:16.0%
Extinguishing Media:SM FIRES:USE DRY CHEM, CO*2, WATER
    SPRAY/ALCOHOL-RESIST FOAM. USE WATER SPRAY TO COOL FIRE-EXPOS
    CNTNRS. WATER MAY BE INEFFECTIVE. DO NOT USE STRAIGHT STREAMS OF
    WATER. LG (SUPDAT)
Fire Fighting Procedures:USE NIOSH APPROVED SCBA AND FULL PROTECTIVE
    EQUIPMENT . NFPA RATING: HEALTH-2; FLAMMABILITY-3; REACTIVITY-0.
Unusual Fire/Explosion Hazard:CNTNRS CAN BUILD UP PRESS IF EXPOS TO
    HEAT &/OR FIRE. VAPS MAY FORM EXPLO MIX W/AIR. VAPS CAN TRAVEL TO
    IGNIT SOURCE & FLASH BACK. COMBUST GENERATES TOX FUMES. USE WATER
    SPRAY TO KEEP FIRE-EXPOS CNTNR S COOL. FLAM LIQ. VAPS MAY BE
    HVR/AIR. THEY CAN SPREAD ALONG GROUND & COLLECT IN LOW/CONFINED
    AREAS. CNTNRS MAY (SUPDAT)

==================  Accidental Release Measures  ==================

Spill Release Procedures:USE PROPER PERSONAL PROTECTIVE EQUIPMENT.
    AVOID RUNOFF INTO STORM SEWERS AND DITCHES WHICH LEAD TO WATERWAYS.
    REMOVE ALL SOURCES OF IGNITION. ABSORB SPILL USING AN ABSORBENT,
    NON-COMBUSTIBLE MATERIAL  SUCH AS EARTH, SAND OR VERMICULITE. A
    VAPOR SUPPRESSING FOAM MAY BE USED TO REDUCE VAPORS. WATER SPRAY
    MAY REDUCE VAPOR BUT MAY NOT PREVENT IGNITION IN CLOSED SPACES.

======================	Handling and Storage  ======================

Handling and Storage Precautions:KEEP AWAY FROM HEAT, SPKS & FLAME.
    KEEP AWAY FROM SOURCES OF IGNIT. STORE IN TIGHTLY CLOSED CNTNR.
    KEEP FROM CNTCT W/OXIDIZING MATLS. STORE IN COOL, DRY, WELL-VENTD
    AREA AWAY FROM INCOMPAT SUBSTANCES.  WASH THOROUGHLY AFTER HNDLG.
    REMOVE CONTAM CLTHG & WASH BEFORE USE. USE ONLY IN WELL VENTD AREA.
Other Precautions:GROUND & BOND CNTNRS WHEN TRANSFERRING MATL. AVOID
    CNTCT W/EYES, SKIN & CLTHG. EMPTY CNTNRS RETAIN PROD RESIDUE (LIQ
    &/OR VAP) & CAN BE DANGEROUS. KEEP CNTNR TIGHTLY CLSD. AVOID CNTCT
    W/HEAT, SPKS & F LAME. DO NOT INGEST/INHALE. DO NOT PRESSURIZE,
    CUT, WELD, BRAZE, SOLDER, DRILL, GRIND/EXPOSE EMPTY C NTNRS TO
    (SUPDAT)

=============  Exposure Controls/Personal Protection  =============

Respiratory Protection:FOLLOW THE OSHA RESPIRATOR REGULATIONS FOUND IN
    29 CFR 1910.134 OR EUROPEAN STANDARD EN 149. ALWAYS USE A NIOSH OR
    EUROPEAN STANDARD EN 149 APPROVED RESPIRATOR WHEN NECESSARY.
Ventilation:USE ADEQ GEN/LOC EXHST VENT TO KEEP AIRBORNE CONCS BELOW
    PEL. ACETONITRILE: EXPOS LIMS: ACGIH-40PPM; 67 MG/M3; 60PPM STEL;
    101 MG/M3 STEL. NIOSH-20PPM (SUPDAT)
Protective Gloves:IMPERVIOUS GLOVES .
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:ANSI APPROVED EYE WASH AND DELUGE SHOWER .
    WEAR APPROPRIATE PROTECTIVE CLOTHING TO PREVENT SKIN EXPOSURE.
Supplemental Safety and Health
OTHER PRECS:HEAT, SPKS/OPEN FLAME. EXTING MEDIA:FIRES:USE DRY CHEM,
    CO*2, ALCOHOL-RESIST FOAM/WATER SPRAY. COOL CNTNRS W/FLOODING QTYS
    OF WATER UNTIL WELL AFTER FIRE IS OUT. EXPLO HAZ:MAY EXPLODE WHEN 
    HEATED. VENT:TWA; 34MG/M3 TWA; 500PPM IDLH. OSHA-40PPM TWA; 70
    MG/M3 TWA. OSHA VACATED PELS:40PPM TWA; 70MG/M3 TWA.

==================  Physical/Chemical Properties  ==================

Melt/Freeze Pt:=-50.C, -58.F
Decomp Temp:Decomp Text:NOT AVAILABLE
Vapor Pres:73 MM HG
Vapor Density:1.4(AIR=1)
Spec Gravity:0.7810
pH:NOT AVAILABLE
Viscosity:0.36 CP 20 DEG
Solubility in Water:SOLUBLE
Appearance and Odor:CLEAR, COLORLESS LIQUID; SWEETISH ODOR - AROMATIC
    ODOR.

=================  Stability and Reactivity Data  =================

Stability Indicator/Materials to Avoid:YES
CHLORINE FLUORIDE, FLUORINE, 2-CYANO-2-PROPYL NITRATE, DINITROGEN
    TETRAOXIDE, INDIUM, DIPHENYL SULFOXIDE, TRICHLOROSILANE, N-FLUORO
    CMPDS, IRON (III) PERCHLORATE, LANTHANIDE, NITRIC ACID, PERCHLORIC
    ACID, SULFURIC ACID, SUL
Stability Condition to Avoid:STABLE UNDER NORMAL TEMPERATURES AND
    PRESSURES. AVOID INCOMPATIBLE MATERIALS, IGNITION SOURCES.
Hazardous Decomposition Products:HYDROGEN CYANIDE, NITROGEN OXIDES,
    CARBON MONOXIDE, CARBON DIOXIDE.

===================  Toxicological Information	===================

Toxicological Information:CAS #75-05-8, RTECS #AL7700000. LD50/LC50 -
    INHAL, MOUSE: LC50=2693 PPM/1H; INHAL, RABBIT: LC50=2828 PPM/4H;
    INHAL, RAT: LC50=7551 PPM/8H; ORAL, MOUSE: LD50=269 MG/KG; ORAL,
    RABBIT: LD50=50 MG/KG; ORA L, RAT: LD50=2730 MG/KG; SKIN,
    RABBIT:LD50=1250 MG/KG; CARCINOGENICITY - ACGIH: A4 - NOT
    CLASSIFIABLE AS HUMAN CARCIN. EPIDEMIOLOGY - NO INFO AVAIL.
    TETRAGENICITY - EMBRYO OR FETUS: STUNTED FETUS, IHL -HAMSTER
    TCLO=8000 PPM/1H. SPECIFIC DEVELOPMENTAL ABNORMS: MUSCULOSKELETAL,
    ORL-HAMSTER TCLO=300 MG/KG. REPRO EFTS - FERTILITY:
    POST-IMPLANTATION MORTALITY, ORL-HAMSTER TDLO=400 MG/KG &
    IHL-HAMSTER TC LO=5000 PPM/1H. (OTHER INFO)

=====================  Ecological Information  =====================

Ecological:EXOTOXICITY: FATHEAD MINNOW (HARD WATER) TLM=1150 PPM/24H.
    ENVIRONMENTAL FATE: NO INFO REPORTED. PHYSICAL/CHEMICAL: NO INFO
    AVAIL. OTHER: NONE. OTHER INFO: ADVICE IMMED (SHOW LABEL WHERE
    POSS). WGK (W ATER DANGER/PROT) CAS #75-05-8: 2. CANADA: CAS
    #75-05-8 IS LISTED ON CANADA'S DSL/NDSL LIST, HAS A WHMIS
    CLASSIFICATION OF B2, D1B, D2B. IT IS NOT LISTED ON CANADA'S INGRED
    DISCLOSURE LIST. EXPOS LIMS : CAS #75-05-8: OEL-ARAB REPUBLIC OF
    EGYPT:TWA 40 PPM (70 MG/M3); SKIN OEL-AUSTRALIA: TWA 40 PPM (70
    MG/M3); STEL 60 PPM; SKIN OEL-AUSTRIA; TWA 40 PPM (70 MG/M3)
    OEL-BELGIUM:TWA 40 PPM (67 MG/M3); STE L 60 PPM (10 MG/M3);
    (TRANSPORT INFO)

====================  Disposal Considerations  ====================

Waste Disposal Methods:DISPOSE OF IN A MANNER CONSISTENT WITH FEDERAL,
    STATE AND LOCAL REGULATIONS. RCRA D-SERIES MAXIMUM CONCENTRATION OF
    CONTAMINANTS: NONE LISTED. RCRA D-SERIES CHRONIC TOXICITY REFERENCE
    LEVELS: NONE LIS TED. RCRA F-SERIES: NONE LISTED. RCRA P-SERIES:
    NONE LISTED. RCRA U-SERIES: CAS #75-05-8: WASTE #U00 3 (IGNITABLE
    WASTE; TOXIC WASTE).

===================  MSDS Transport Information  ===================

Transport Information:SHIPPING NAME - US DOT: ACETONITRILE; IATA: NO
    INFO AVAIL; RID/ADR: NO INFO AVAIL. IMO: NO INFO AVAIL.
    ACETONITRILE. HAZ CLASS - US DOT: 3; IMO: 3(6.1). UN NUMBER: US
    DOT: UN1648; IMO: UN1648. PACKING  GROUP: US DOT: II; IMO: II.
    ADDNL INFO: IMO: FLASHPOINT 6C. ECOLOGICAL INFO: SKIN
    OEL-DENMARK:TWA 40 PPM (70 MG/M3); STEL 60 PPM (10 MG/M3);
    OEL-FINLAND: TWA 40 PPM (70 MG/M3); STEL 60 PPM (10 MG/M3) ;
    OEL-FRANCE: TWA 50 MG/M3; STEL 100 MG/M3; SKIN JAN9 OEL-THE
    NETHERLANDS: TWA 40 PPM (70 MG/M3) OEL-THE PHILIPPINES: TWA 40 PPM
    (70 MG/M3) OEL-RUSSIA: STEL 10 MG/M3; OEL-SWITZERLAND: TWA 40 PPM
    (70 M G/M3); STEL 80 PPM; (STATE REG INFO)

=====================  Regulatory Information  =====================

SARA Title III Information:CAS #75-05-8: SARA SECTION 302(RQ): FINAL
    RQ=5000 LBS (2270 KG). SECTION 302(TPQ): NONE OF CHEMICALS IN
    PRODUCT HAVE TPQ. SARA CODES: ACUTE, CHRONIC, FLAMMABLE. SECTION
    313: MATERIAL CONTAINS ACETONIT RILE (CAS #75-05-8, 99%) WHICH IS
    SUBJECT TO REPORTING REQS OF SECTION 313 OF SARA TITLE III & 40 CFR
    PART 373.
Federal Regulatory Information:CAS #75-05-8: TSCA: LISTED ON TSCA
    INVENTORY. HLTH & SFTY REPORTING LIST: EFTIVE DATE: OCT 4, 1982;
    SUNSET DATE: OCT 4, 1992. CHEM TEST RULES: NONE OF CHEMS IN PROD
    UNDER CHEM TEST RULE. SECTION 12B:	NONE OF CHEMS LISTED UNDER TSCA
    SECTION 12B. TSCA SIGNIFICANT NEW USE RULE: NONE OF CHEMS IN MATL
    HAVE SNUR UNDER TSCA. CLEAN AIR ACT: LISTED AS HAZ AIR POLLUTANT
    (HAP). MATL DOES NOT CNTN ANY CLASS 1  OR CLASS 2 OZONE DEPLETORS.
    CLEAN WATER ACT: NONE OF CHEMS IN PROD LISTED AS HAZ SUBSTANCES
    UNDER C WA. NONE OF CHEMS LISTED AS PRIORITY OR TOX POLLUTANTS
    UNDER CWA. NONE CONSIDERED HIGHLY HAZ BY OSHA.
    EUROPEAN/INTERNATIONAL  (OTHER INFO)
State Regulatory Information:CAS #75-05-8 CAN BE FOUND ON FOLLOWING
    STATE RIGHT TO KNOW LISTS: CALIFORNIA, NEW JERSEY, FLORIDA,
    PENNSYLVANIA, MINNESOTA, MASSACHUSETTS. CALIFORNIA NO SIGNIFICANT
    RISK LEVEL: NONE OF CHEMS IN THIS P ROD ARE LISTED. TRANSPORT INFO:
    SKIN OEL-TURKEY: TWA 40 PPM (70 MG/M3) OEL-UNITED KINGDOM:TWA 40
    PPM (70 MG/M3); STEL 60 PPM; OEL IN BULGARIA, COLOMBIA, JORDAN,
    KOREA CHECK ACGIH. TLV OEL IN NEW ZEALA ND, SINGAPORE, VIETNAM
    CHECK ACGIH TLV.

=======================  Other Information  =======================

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